大蒜，洋葱和谷物纤维作为乳腺癌的保护因子：一项法国病例对照研究。,European Jo

大蒜，洋葱和谷物纤维作为乳腺癌的保护因子：一项法国病例对照研究。
European Journal of Epidemiology ( IF 7.7 ) Pub Date : 1999-02-03 , DOI: 10.1023/a:1007512825851
B Challier 1 , J M Perarnau , J F Viel

Affiliation  

Department of Public Health, Faculty of Medicine, Besançon,

在1986年至1989年之间的法国东北部（洛林）对345例诊断为原发性乳腺癌的患者进行的病例对照研究中，调查了饮食对乳腺癌风险的作用。对于每种情况，一个对照都匹配年龄（+/- 3岁）和社会经济地位。饮食史问卷包括一份自我管理的食物频率问卷，一份为期6天的食物日记和一份能量消耗记录。它还引起了个人特征和病史。在考虑总热量摄入和已确定的危险因素的情况下，乳腺癌风险随着纤维摄入（趋势的p值= 0.03）以及大蒜和洋葱（趋势的p值<10（-6））的增加而降低。这项研究还支持了流行病学证据，即绝经后妇女的饱和脂肪摄入量与乳腺癌风险相关（趋势的p值= 0.03）。相反，这表明不饱和脂肪的摄入可以降低同一亚组的风险（趋势的p值= 0.03）。我们对乳腺癌保护因子的发现可以诱导出有效的预防措施，并有必要进行进一步的实验研究以分离出特定的亚型。

Garlic, onion and cereal fibre as protective factors for breast cancer: a French case-control study.

The role of diet on breast cancer risk was investigated in a case-control study of 345 patients diagnosed with primary breast carcinoma between 1986 and 1989 in the north-east of France (Lorraine). For each case, one control was matched for age (+/-3 years) and socio-economic status. The dietary history questionnaire consisted of a self-administered food frequency questionnaire, a 6-day food diary and an energy expenditure record. It also elicited personal characteristics and medical history. While taking into account total caloric intake and established risk factors, breast cancer risk was shown to decrease as consumption of fibre (p value for trend = 0.03), and garlic and onions (p value for trend